Research Focus The primary research goal of my lab is to study the fundamental mechanisms of post- transcriptional regulation of gene expression with an emphasis on RNA processing factors mutated in complex brain disorders. Specifically, we are interested in the post-transcriptional activities of the RNA- regulatory RNA exosome complex in human neurodevelopment and disease. In my lab, we have taken the strategy of coupling in vivo Drosophila genetics with in vitro human iPSC-derived brain organoid models to understand how defects in subunits of the ubiquitous and essential RNA exosome complex cause tissue-specific consequences.